4-HPR dose 150 mg/Kg | ||||
---|---|---|---|---|
Single acute treatment | 2 weeks of treatment daily | |||
Parameters | NCI-FeR | Bio-nFeR | NCI-FeR | Bio-nFeR |
Cmax (ng/ml) SD | 3456.8 ± 1453.3 | 6350 ± 4153.9 | 4306.4 ± 1150.7 | 6813.3 ± 1200.9 |
Tmax (hr) | 2 | 2 | 2 | 4 |
AUC inf (hr*ng/ml) | 46873.8 | 59371 | 53554.7 | 85378.7 |
AUC 24 h (hr.*ng/ml) | 43257.7 | 56880.7 | 45436.7 | 78608.3 |
HL (hr) | 6.4 | 5.3 | 8.3 | 5.7 |
R* | 1.3 | 1.6 |