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Table 2 Pharmacokinetic comparison of Bio-nFeR and NCI-Fer in single versus chronic treatment

From: A novel oral micellar fenretinide formulation with enhanced bioavailability and antitumour activity against multiple tumours from cancer stem cells

 

4-HPR dose 150 mg/Kg

Single acute treatment

2 weeks of treatment daily

Parameters

NCI-FeR

Bio-nFeR

NCI-FeR

Bio-nFeR

Cmax (ng/ml) SD

3456.8 ± 1453.3

6350 ± 4153.9

4306.4 ± 1150.7

6813.3 ± 1200.9

Tmax (hr)

2

2

2

4

AUC inf (hr*ng/ml)

46873.8

59371

53554.7

85378.7

AUC 24 h (hr.*ng/ml)

43257.7

56880.7

45436.7

78608.3

HL (hr)

6.4

5.3

8.3

5.7

R*

1.3

1.6

  1. Pharmacokinetic parameters determination in mice after single oral treatment of Bio-nFeR at dose of 150 mg/kg or after 2 weeks treatment, in comparison to the NCI-FeR formulation
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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