Fig. 7From: Knockdown of circDENND4C inhibits glycolysis, migration and invasion by up-regulating miR-200b/c in breast cancer under hypoxiamiR-200c exhaustion attenuates silence of circDENND4C-modulated progression suppression in breast cancer cells under hypoxia. Glucose consumption (a and b), lactate production (c and d), HK2 protein level (e and f), cell migration (g and h), invasion (i and j) and protein levels of MMP9 and MMP2 (k and l) were detected in MDA-MB-453 and SK-BR-3 cells transfected with siRNA negative control (si-NC), siRNA against circDENND4C (si-circ), si-circ and miR-200c inhibitor (anti-miR-200c) or inhibitor negative control (anti-miR-NC) by special commercial kits, western blot and trans-well assay, respectively. *P < 0.05, **P < 0.01, ***P < 0.001Back to article page