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Table 3 The altered networks based on the miRNA signature of the bladder cancer participants, where the relevance score was generated using IPA. Each network integrates miRNAs along with the most relevant target genes, indicating disease or biological function, based on which the score is calculated

From: Connecting the dots between different networks: miRNAs associated with bladder cancer risk and progression

ID Top Diseases and Functions Score Focus Molecules Molecules in Network
1 Organismal Injury and Abnormalities, Reproductive System Disease, Cancer 29 12 ↑let-7a-5p*, mir-143, mir-145, mir-205, mir-761, ↓miR-133a-3p, ↑miR-141-3p*, ↓miR-143-5p, ↓miR-145-3p, ↑miR-181a-5p, ↑miR-19b-3p, ↑miR-200b-3p*,↑ miR-205-5p, ↑miR-21-5p, ↓miR-214-3p, ↑miR-23a-3p, PITX1, PTPRD, Ras, RDH10, resolvin D1, WDR37, ZFPM2
2 Cancer, Organismal Injury Abnormalities, Cell Cycle 6 3 BRF1, CDK2, Ck2, MIR3162, mir-25, mir-193, mir-506, ↓ miR-193a-5p, ↑miR-3162-5p, ↑miR-513a-5p, RNA polymerase iii, SSB, TP53
3 Organismal Injury and Abnormalities, Reproductive System Disease, Developmental Disorder 3 1 mir-548, ↓miR-548q
4 Organismal Injury and Abnormalities, Reproductive System Disease, Cancer 3 1 mir-191, ↑miR-191-3p
5 Developmental Disorder, Hereditary Disorder, Organismal Injury, Abnormalities 3 1 miR-1225, ↑mir-1225-5p
6 Cancer, Cell Cycle, Cell Death and Survival 3 1 CDKN2A, mir-1246, ↑miR-1246
7 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities 3 1 MIR1234, MIR7170, ↑miR-1234-3P
8 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities 3 1 mir-630, ↑miR-630, TMEM8B
9 Cancer, Connective Tissue Disorders, Hematological Disease 2 1 miR-4665, miR-6941, miR-7023, miR-7024, miR-7119, miR-1275, ↑miR-1275, YBX1