Fig. 7

High HK2 expression is inversely correlated with the number of CD8⁺ TILs in patients samples and high glycolysis signature is inversely related with CD8A expression in TCGA dataset. a The numbers of CD8⁺ TILs were evaluated according to PD-L1 and HK2 expression status using tumor tissues from patients with pSqCC. Statistical significance was calculated using Kruskal-Wallis tests. b HK2 expression was evaluated according to PD-L1 expression and the numbers of CD8⁺ TILs using tumor tissues from patients with pSqCC. Statistical significance was calculated using Kruskal-Wallis tests. c & d CD8A transcript levels were compared according to CD274 (PD-L1)/glycolysis signature and the glycolysis signature was compared according to the tumor microenvironment immune type (TMIT) based on CD274 (PD-L1)/CD8A expression status c in pADC and d in pSqCC from TCGA dataset. Statistical differences were analyzed using Kruskal-Wallis tests. *p < 0.05; **p < 0.001. Abbreviations: N, negative; P, positive; L, low; H, high