Fig. 3
Overexpression of METTL3 promoted the migration and invasion ability of CRC cell lines in intro and in vivo. (a) Overexpression of METTL3 in DLD-1 and HCT116 cell lines. (b) transwell migration and invasion assays in METTL3-overexpressing cell lines. Original magnification 200X; scale bar: 50 μm. (c) Scratch wound healing assay in METTL3-overexpressing cell lines. Original magnification, 40X; scale bar: 100 μm. (d) Stable overexpression of METTL3 in HCT-116 cell line, the METTL3 level was shown (e) Hepatic metastasis foci in metastasis model graphs were shown. Right panel showed the metastasis foci formed in the liver were compared between oeVec and oeMETTL3 group. Black dot indicated the metastatic foci. Data are presented as means ± standard deviation (*P < 0.05, **P < 0.01)