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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway

Fig. 7

The schematic model of METTL3 in regulating CRC. METTL3 methylate pri-miR-1246 in its upstream, marking them for recognition and processing. Overexpression of METTL3 increases the level of miR-1246 by promoting the maturation of miR-1246 from pri-miR-1246. miR-1246 decreases the expression of anti-oncogene SPRED2, thus resulting in cell migration and invasion in CRC

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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