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Table 1 Metabolism targeting approaches of T cell and tumor cells

From: Targeting T cell metabolism in the tumor microenvironment: an anti-cancer therapeutic strategy

Name Target Signaling pathway Effect
PD-1/PD-L1 Anitibodies PD-1/PD-L1 PI3K/Akt/mTOR Teffs: increase FAO
Tumor: inhibit glycolysis
CTLA-4 Antibodies CTLA-4 PI3K/Akt/mTOR Teffs: inhibit glucose uptake
Imatinib BCR-ABL kinase/IDO BCR/ABL IDO Teffs: activate
Treg: apoptosis
Tumor: switching from glycolysis to OXPHOS
Metformin PD-L1 LKB1-AMPK system mTOR Tumor: down-regulate PD-L1 expression
PIM kinase inhibitor PIM kinase mTORC1 Teffs: increase glucose uptake
Enzyme phosphoenolpyruvate carboxykinase-1 Phosphoenolpyruvate Sarco/ER Ca(2+)-ATPase (SERCA) activity Teffs: upregulate the effector function
MVK inhibitor MVK PI3K/Akt/mTOR Teffs: promote activation
Tumor: inhibit
Avasimibe ACAT-1 Cholesterol esterification Teffs: activate
Tumor: inhibit the proliferation and metastasis
GDC-0919 IDO1 tryptophan Teffs: relieves CD8+ T cell inhibition
INCB024360 IDO tryptophan Teffs: increase proliferation and IFN-γ production
N-acetylcysteine FOXO1 PI3K/Akt/mTOR Teffs: affect granzyme B secretion and PD-1 expression