Fig. 3

Knockdown MEIS2C/D suppressed malignant behaviors of HCC cells in vivo. a Representative image showing xenografts in nude mice were established by subcutaneous injection of shMEIS2C/D and control HCC-LM3 cell lines (n = 8). Comparisons of overall survival curves in mice (n = 10). P values were calculated using the Log-rank test. b Representative image showing visible intrahepatic metastases in the HCC-LM3-shMEIS2C/D and control groups (n = 5). c MHCC97H-shMEIS2C/D and control cells were injected subcutaneously in nude mice and tumor volume was evaluated after injection (n = 6). Comparisons of overall survival curves in mice injection of MHCC97H-shMEIS2C/D and control groups (n = 10). d Representative image and H&E stain showing spontaneous lung metastasis in matched subcutaneous nude mice model (n = 5)