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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Apatinib potentiates irradiation effect via suppressing PI3K/AKT signaling pathway in hepatocellular carcinoma

Fig. 2

Apatinib suppresses repair of radiation-induced DNA double-strand breaks. a The representative images of γ-H2AX foci immunofluorescence staining in SMMC-7721, MHCC-97H, HCCLM3 and Hep-3B cells treated with IR (4 Gy) or in combination with apatinib at 1 h and 24 h after IR. b Cells with more than 10 γ-H2AX foci were counted and then quantified. c Western blot showed the combination treatment further enhanced γ-H2AX formation 1 h and 24 h after IR. Error bars indicate SEM, *p < 0.05

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