Fig. 2

Apatinib suppresses repair of radiation-induced DNA double-strand breaks. a The representative images of γ-H2AX foci immunofluorescence staining in SMMC-7721, MHCC-97H, HCCLM3 and Hep-3B cells treated with IR (4 Gy) or in combination with apatinib at 1 h and 24 h after IR. b Cells with more than 10 γ-H2AX foci were counted and then quantified. c Western blot showed the combination treatment further enhanced γ-H2AX formation 1 h and 24 h after IR. Error bars indicate SEM, *p < 0.05