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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Targeting CXCR4 potentiates anti-PD-1 efficacy modifying the tumor microenvironment and inhibiting neoplastic PD-1

Fig. 5

Pep R in combination with anti-PD-1 treatment mediated the impairment of infiltrating immune-suppressive cells in B16-hCXCR4 tumors. Flow cytometry analysis of single-cell suspensions from digested B16-hCXCR4 tumors (n = 6/group) stained as described in Material and Methods. The histograms represent the frequencies (mean ± SEM) of %: (a) Tregs/CD45+; MDSCs/CD45+; pDC/CD45+; neutrophil/CD45+; (b) CD8+/Treg, and CD8+/MDSCs; Mann-Whitney U test P < 0.05

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