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Table 3 RNA sequencing data showing significant changes in expression mouse (MBMEC) and human (HBMEC) endothelial cells

From: Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases

 

mouse

human

log2fc

p-value

log2fc

p-value

Tubb2b

1.315

< 0.001

1.725

< 0.001

Tubb2a

1.212

< 0.001

1.523

< 0.001

Tuba4a

1.472

< 0.001

1.231

< 0.001

Tuba1a

1.231

< 0.001

1.364

< 0.001

Tspan2

−0.475

0.028

−1.513

0.007

  1. Differential expression analysis of mRNA levels of mouse (DTX, n = 3; ctrl, n = 2; DTX, 500 ng/mL) and human (DTX, n = 2; ctrl, n = 2; DTX, 50 ng/mL) primary cultured ECs after 24 h of DTX-treatment. Analysis was done using DESeq2 package, based on PCA plot. Outliers were excluded resulting in the above stated n