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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: NANOG helps cancer cells escape NK cell attack by downregulating ICAM1 during tumorigenesis

Fig. 2

NANOG overexpression induces tumorigenic potential by allowing escape from NK cell attack. (a) Western blot analyses of WT-, GFP- and GN-DU145 cells. (b) The proliferation rates of DU145 cells (WT, GFP, and GN) were compared (n = 3, Tukey-Kramer test). (c) The cell viabilities of DU145 cells (WT, GFP, and GN) were measured after performing the NK cell resistance assay in vitro (n = 3, *P < 0.005, **P < 0.001, Tukey-Kramer test). (d) GFP- and GN-DU145 cells were transplanted onto SCID mice treated with an anti-asialo GM1 Ab or control IgG. Respective tumor volumes were measured for up to 60 days after the transplantation (n = 4, *P < 0.05, **P < 0.01, Student’s t test)

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