Fig. 2
From: NANOG helps cancer cells escape NK cell attack by downregulating ICAM1 during tumorigenesis
NANOG overexpression induces tumorigenic potential by allowing escape from NK cell attack. (a) Western blot analyses of WT-, GFP- and GN-DU145 cells. (b) The proliferation rates of DU145 cells (WT, GFP, and GN) were compared (n = 3, Tukey-Kramer test). (c) The cell viabilities of DU145 cells (WT, GFP, and GN) were measured after performing the NK cell resistance assay in vitro (n = 3, *P < 0.005, **P < 0.001, Tukey-Kramer test). (d) GFP- and GN-DU145 cells were transplanted onto SCID mice treated with an anti-asialo GM1 Ab or control IgG. Respective tumor volumes were measured for up to 60 days after the transplantation (n = 4, *P < 0.05, **P < 0.01, Student’s t test)