Fig. 7
From: NANOG helps cancer cells escape NK cell attack by downregulating ICAM1 during tumorigenesis
ICAM1 expression correlates with malignancy and recurrence in PCa patients (a) Correlation between ICAM1 expression levels and grades of PCa (localized and CRPC) malignancy in published microarray data. (b) Kaplan-Meier curves of the progression-free survival rates of TCGA PCa patients with high or low ICAM1 expression divided by the median. Log, log-rank test. (c) Model of escape system of PCa from NK cell attack. NANOG-low PCa cells are efficiently identified and destroyed by NK cells via ICAM1 expression. NANOG-high PCa cells downregulate ICAM1 expression and evade NK cell attak