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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: NANOG helps cancer cells escape NK cell attack by downregulating ICAM1 during tumorigenesis

Fig. 7

ICAM1 expression correlates with malignancy and recurrence in PCa patients (a) Correlation between ICAM1 expression levels and grades of PCa (localized and CRPC) malignancy in published microarray data. (b) Kaplan-Meier curves of the progression-free survival rates of TCGA PCa patients with high or low ICAM1 expression divided by the median. Log, log-rank test. (c) Model of escape system of PCa from NK cell attack. NANOG-low PCa cells are efficiently identified and destroyed by NK cells via ICAM1 expression. NANOG-high PCa cells downregulate ICAM1 expression and evade NK cell attak

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