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Table 2 Effect of MCPIP1 on gene expression. Regulation of genes expression and proteins level by MCPIP1 was tested both in cells with ZC3H12A overexpression or silencing. Cited results were obtained from studies using cells cultured in control conditions. We did not include data obtained upon induction of differentiation (i.e. adipogenesis), nor stimulation (i.e. cytokines, LPS)

From: Activity of MCPIP1 RNase in tumor associated processes

MCPIP1 OVEREXPRESSION
protein level Experimental model Reference
  cdh12, cdh19, VE-cadherina HUVECs Niu et al., 2008 [27]
  Flt-1, Flk-1, Tie-2, VEGF, Beclin-1a bone marrow mononuclear cells Niu et al., 2013 [28]
  CD31, VE-cadherinb
  HIF1α, SIRT-1a HUVECs Roy, 2013 [29]
  Ras-related protein Rab-11B, Testinc, e mesenchymal stem cells Labedz-Maslowska et al., 2015 [35]
  Endothelin, IP-10, TIPM-1, MMP-3, NOVa
  Pro-Caspase-3a MDA-MB-231, 4 T1 cell line Lu et al., 2016 [30]
  PARP1a 4 T1 Lu et al., 2016 [30]
  DFFB, APAF1a BE(2)-C human neuroblastoma cell line Boratyn et al., 2016 [31]
  E-cadherina ccRCC cell line Caki-1 Marona et al., 2017 [34]
  p21a ccRCC cell line Caki-1 Lichawska-Cieslar et al., 2018 [32]
protein level Experimental model Reference
  PAI-1, iNOSa HUVECs Qi et al., 2010 [36]
  TSP-1, VEGI, p65a HUVECs Roy et al., 2013 [29]
  CAAX prenyl protease 1 homolog, Calumeninc, f   KCa mesenchymal stem cells Labedz-Maslowska et al., 2015 [35]
  HIF1α, HIF2αa ccRCC cell line Caki-1 Ligeza et al., 2017 [33]
  c-Met, Src, βcatenin, Vimentin, c/EBPβa ccRCC cell line Caki-1 Marona et al., 2017 [34]
  p53, p21a human primary keratinocytes Bugara et al., 2017 [37]
MCPIP1 SILENCING
protein level Experimental model Reference
  c-Met, Src, βcatenin, Vimentina c/EBPβa ccRCC cell line Caki-1 Marona et al., 2017 [34]
  IL-8, VEGF, IL-6d
  Cyclin D1a human primary keratinocytes Bugara et al., 2017 [37]
  IL-8d
  VCAM-1a HUVECs Li et al., 2018b [38]
protein level Experimental model reference
  E-cadherina ccRCC cell line Caki-1 Marona et al., 2017 [34]
  1. awestern blot analysis
  2. bimmunofluorescence analysis
  3. cproteomic analysis by mass spectroscopy
  4. dELISA
  5. efold change > 5
  6. ffold change <−5