Upregulation of CENPM promotes hepatocarcinogenesis through mutiple mechanisms

Table 1 Univariate and multivariate analyses of clinicopathological characteristics, and CENPM with overall survival in TCGA LIHC cohort

	Univariate analysis		Multivariate analysis
Characteristics	HR (95% CI)	p-value	HR (95% CI)	p-value
Gender
(male vs female)	0.862 (0.595–1.249)	0.434
Age, years
(≥median vs. < median)	1.012 (0.998–1.027)	0.102
Risk factors
(alcohol consumption vs non-alcohol consumption)	1.114 (0.828–1.499)	0.476
Histologic grade
(G1 + G2 vs G3 + G4)	1.215 (0.879–1.414)	0.0389*
Clinical stage
(stage I + II vs stage III + IV)	1.381 (1.149–1.660)	0.000*
Pathologic T stage (present vs. absent)	1.673 (1.393–2.010)	0.000*	1.645 (1.192–2.269)	0.002*
Pathologic N stage (present vs. absent)	0.140 (0.045–0.442)	0.007*	0.169 (0.038–0.740)	0.018*
Pathologic M stage (present vs. absent)	0.089 (0.0221–0.362)	0.000*	0.335 (0.10–1.126)	0.070*
CENPM
(≥median vs. < median)	1.043 (1.014–1.073)	0.003*	1.025 (0.799–1.057)	0.032*

HR, Hazard ratio, CI, Confidence interval. Bold italics indicate statistically significant values (*p < 0.05)

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