Fig. 3
From: Attenuation of hedgehog/GLI signaling by NT1721 extends survival in pancreatic cancer
NT1721 reduced PDAC cell viability and hedgehog/GLI signaling significantly better than clinically used hedgehog inhibitors. a Viability of Panc1 and Capan1 cells treated with NT1721, erismodegib or vismodegib. b PTCH1 and BCL2 mRNA expression in and Capan1 cells treated with NT1721, erismodegib or vismodegib. c Capan1 GLI reporter cells were treated with NT1721, erismodegib or vismodegib. The bioluminescence was measured after 48 h and normalized to the control. The graphs represent the mean ± SD from triplicate values