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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: STRA6 exerts oncogenic role in gastric tumorigenesis by acting as a crucial target of miR-873

Fig. 5

STRA6 knockdown inhibit Wnt/β-catenin signalling pathway and EMT progression. a GSEA analysis of STRA6 expression based on TCGA cohort (left panel, p value< 0.001; left panel, p value< 0.05). b The correction of expression between STRA6, β-catenin, N-cadherin and vimentin. c The effect of STRA6 on Wnt/β-catenin signalling activity was evaluated by TOP-flash/FOP-flash luciferase reporter assay. d Protein level of biomarkers of EMT and Wnt/β-catenin signalling was detected by western blot. e-g Immunofluorescence staining with β-catenin, N-cadherin, vimentin (Red) and DAPI nuclear staining (blue). (*p < 0.05, **p < 0.01, ***p < 0.001. The data expressed as the mean ± SD)

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