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Table 2 Univariate and multivariate analysis of different prognostic parameters in 168 HCC patients

From: Correction to: KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity

Variable Univariate analysis   Multivariate analysis
All cases Mean survival (months) p Value HR (95% CI) p Value
Age (years)    0.339   
 ≤ 51 90 49.799    
 > 51 78 69.089    
Sex    0.061   
 Male 143 69.106    
 Female 25 43.696    
AFP (ng/ml)    0.055   
 ≤ 20 72 72.295    
 > 20 96 53.431    
HBsAg    0.329   
 negative 11 59.111    
 positive 157 66.402    
Cirrhosis    0.829   
 No 99 57.617    
 Yes 69 66.272    
Necrosis    0.179   
 No 76 60.350    
 Yes 92 63.514    
Clinical stage    0.000   0.000
 I-II 111 65.813   1  
 III-IV 57 43.778   5.173 (2.456–10.894)  
Histologic grade (WHO)    0.000   0.035
 G1-G2 82 65.254   1  
 G3-G4* 86 55.882   2.334 (1.063–5.126)  
Tumor size (cm)    0.017   0.915
 ≤ 5 73 74.428    
 > 5 95 49.049    
Tumor multiplicity    0.000   0.478
 Unifocal 128 61.089    
 Multifocal 40 50.483    
Intravascular emboli    0.013   0.483
 No 100 61.257    
 Yes 68 59.172    
Recurrence    0.007   0.061
 No 125 70.974    
 Yes 43 44.667    
KIFC1    0.002   0.012
 Low   74.153   1  
 High   45.568   2.371 (1.207–4.660)  
  1. *:including 3 cases sarcomatoid liver cancer