Fig. 8

Schematic diagram of the molecular mechanisms underlying NOTCH2-regulated EMT. In NPC cells, NOTCH2 interacts with TRAF6; however, NOTCH2 expression is dramatically reduced upon carcinogenic factor stimulus. TRAF6 activates the non-canonical AKT pathway. AKT activation leads to the induction of vimentin and repression of E-cadherin, which are necessary for cancer cell EMT and migration