Fig. 3

MFAP5 promoted proliferation of ICC cells in vitro and in vivo. a, b Cell viability results showed the different proliferation rate after co-cultured with recMFAP5 and after transfected MFAP5 shRNAs. c, d Colony formation assay results showed the different colony numbers in co-cultured experiments of recMFAP5 and transfected MFAP5 shRNAs cells. e Tumor growth curves after injected ICC cells. f Xenograft tumors from respective groups were shown. g Tumor weight of different xenograft tumors groups. h Boxplot showed Ki-67 level in sh-MFAP5 and sh-Control derived xenograft tumors which evaluated by IHC scores. *P < 0.05,**P < 0.01,***P<0.001