Fig. 4

Overexpression of miR-378e induces cell cycle arrest and apoptosis and suppresses glycolysis, migration and invasion in glioma cells. (a) qRT-PCR assay was performed to detect the level of miR-378e in T98 and U251 cells after transfection of miR-378e or miR-NC. Cell cycle distribution (b and c), glucose consumption (d), lactate production (e), HK2 protein level (f), migration (g), invasion (h) and apoptosis (i) were examined in T98 and U251 cells transfected with miR-378e or miR-NC. Mock is non-transfected group. **P < 0.01, ***P < 0.001 compared with miR-NC group