Fig. 1

Shisa3 expression is associated with EGFR-TKI efficacy and prognosis in lung adenocarcinoma. a. The fold change of gene expression as indicated in 3 tumor tissues with PR compared to 3 tumor tissues with SD, and all the samples were derived from lung adenocarcinoma patients who received EGFR-TKI treatment by the method of transcriptome sequencing analysis. b. The relative expression of shisa3 in 38 paired normal tissues and tumor tissues of lung adenocarcinoma by qRT-PCR analysis. c. Representative images (× 200 magnification) of shisa3 staining by immunohistochemical analysis in tumor tissues. Scale bars, 50 μm. d. The percentages of samples with high and low expression of shisa3 in lung adenocarcinoma patients who received EGFR-TKI treatment (SD, n = 13; PR, n = 32) by immunohistochemical analysis. e, f Kaplan-Meier analysis of the DFS (e) and OS (f) of lung adenocarcinoma patients (n = 102) in connection with shisa3 expression. *p < 0.05; **p < 0.001; ***p < 0.0001