Fig. 6

Mortaparib treatment caused inhibition of cell migration, invasion and angiogenesis in in vitro and tumor suppression in vivo. Mortaparib treatment showed delay in migration (a), invasion (b) in HeLa cells and tube formation (c) in HUVEC cells. Western blot showed decrease in metastasis markers including mortalin, fibronectin, N-cadherin, MMP3, MMP2, MMP7, MMP9, hnRNPK and vimentin in Mortaparib-treated cells (d). Data represents mean ± SD from, at least, three independent experiments; p-values were calculated using Student’s t-test. * < 0.05, ** < 0.01 and *** < 0.001 represent significant, very significant and very very significant, respectively. Mortaparib-treated mice showed decrease in SKOV3 tumor volume with no change in body weight. Representative tumors in control and Mortaparib-treated mice (at day 29) are shown (e). Metastasis of cells to stomach, kidney, lung and spleen was inhibited in Mortaparib-treated mice (F)