ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity

Table 1 Clinicopathological features of OS patients evaluated for YAP expression by immunohistochemistry (IHC) in 175 tissue samples

Characteristics	N	%	Association with prognosis (RFS)^a	Association with survival (OVS)^b
Gender			P = 0.67	P = 0.92
Female	72	41.1
Male	103	58.9
Age			P = 0.37	P = 0.10
≤ 14 years	82	46.9
> 14 years	93	53.1
Surgery			P = 0.47	P = 0.91
Resection	158	90.3
Amputation	12	6.9
Rotation plastic	5	2.8
Margins			P = 0.10	P = 0.36
Adequate	147	84.0
Inadequate	28	16.0
Chemotherapy response (Necrosis)			P = 0.05	P = 0.21
Good	105	60.0
Poor	69	39.4
NA	1	0.6
RFS (status)
NED	90	51.4
REL	85	48.6
OVS (status)
Living	122	69.7
Dead	53	30.3

Associations with prognosis were calculated by univariate analysis using the log-rank test
OS osteosarcoma, NED no evidence of disease, REL relapsed, RFS relapse-free survival, OVS overall survival
^aRFS (median follow-up: 95 months; range 2–415 months)
^bOVS (median follow-up: 156 months; range 7–415 months)

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