Table 1 List of pancRNAs identified in cancer
Name | Cancer Type | Proposed Mechanism | Downstream Effects | Ref. |
|---|---|---|---|---|
pancRNAs_CCDN1 | Cervical cancer | Inhibition of CBP/p300 HAT activity by pancRNA_CCDN1-FUS complex | Repression of Cyclin D1 expression | [28] |
Ewing sarcoma | The pancRNA_CCND1_B/Sam68/DHX9 complex determines a repressive chromatin environment | [29] | ||
pancRNA_Ets-1 | Gastric cancer | NONO-pancRNA_Ets-1 complex interacts with ERG | Activation of ERG-related gene transcription | [46] |
Neuroblastoma | Interaction between pancRNA_Ets-1/hnRNPK complex and β-catenin | Enhanced β-catenin transcriptional activity | [47] | |
FOXCUT | Esophageal squamous cancer | Unknown | Positive correlation with FOXC1 expression | [50] |
Oral squamous cell carcinoma | [51] | |||
Nasopharyngeal carcinoma | [52] | |||
Basal-like breast cancer | [53] | |||
HIF2PUT | Osteosarcoma | Unknown | Positive correlation with HIF-2α expression | |
Colorectal cancer | [58] | |||
pancRNA_CDH1 | Prostate cancer | IsomiR-4534/Ago-pancRNA_CDH1 recruits SUV39H1 | CDH1 transcriptional repression | [59] |
pancRNA_VIM | Colon cancer | R-loop to support an open chromatin state | Enhanced Vimentin transcription | [60] |
Breast cancer | ||||
Khps1 | Cervical cancer, liver cancer and osteosarcoma | DNA-RNA duplex able to interact with p300/CBP | Enhanced E2F1-mediated SPHK1 transcription | [61] |