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Table 1 The NGS Paradox at a glance: a list of benefits and possible pitfalls

From: Variants of uncertain significance in the era of high-throughput genome sequencing: a lesson from breast and ovary cancers

High-throughput technology progress Great challenge for clinical use
Use and development of targeted drugs New mutations with no drugs
Broad tumor characterization Uncertainty in patient outcome
Identification of many diagnostic sub-populations Many small sub-populations with poor statistical power
Simultaneous gene sequencing Time consuming
Cost decrease Not always accessible
Growing number of data Difficult data interpretation and classification
Many newly discovered variants Increase of VUS