Fig. 1

Upregulation of hsa_circ_0000326 was correlated with aggressive characteristics of lung adenocarcinoma. (a) Hierarchical clustering showing different circRNA expression profiles between lung adenocarcinoma tissues and normal tissues. (b) Scatter plots showing the circRNA expression variation between the two compared groups. (c) Volcano plots were used to visualize differential expression between the two different conditions. (d) Expression of hsa_circ_0000326 in the 100 paired human lung adenocarcinoma tissues and adjacent normal tissues. (e) Correlation between hsa_circ_0000326 expression and T classifications (T1-T4) in 100 cases of lung adenocarcinoma tissues and normal lung tissues. (f) Correlation between hsa_circ_0000326 expression and N classifications of lung adenocarcinoma (N0-N3). (g) Correlation between hsa_circ_0000326 expression and differentiation of lung adenocarcinoma. (h) Correlation between hsa_circ_0000326 expression and distant metastasis. (i) Relative hsa_circ_0000326 expression levels in the four lung adenocarcinoma cell lines. *P < 0.05