Fig. 10

The schematic regulation mechanism of the ETV6-miR-429-CRKL regulatory circuitry in HCC. ETV6 directly binds to the promoter region of miR-429 to positively regulate the expression of CRKL by selectively targeting CRKL-3′-UTR; ETV6 upregulates CRKL expression by directly binding to CRKL; which in turn CRKL upregulation promotes ETV6 expression; CRKL overexpression potentially promotes hepatocarcinoma malignancy via activating the ERK pathway