Fig. 7

Knockdown of HOST2 inhibited xenograft tumour growth. a Representative photographs of xenograft tumour after treatment with sh-HOST2 or sh-NC. b Growth curves of tumour proliferation by weeks after treatment with sh-HOST2. c, d The average volumes and weight in sh-HOST2 and sh-NC groups after treatment for 5 weeks. e, f The expression levels of HOST2 and let-7b in xenograft tumour tissues detected by qRT-PCR analysis. g Representative IHC staining of STAT3 stained cells from the indicated tumors (200 × , n = 4). h HOST2 could sponge let-7b, thereby increasing STAT3 expression and promoting TNBC tumorigenesis. ^*P < 0.05