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Table 1 Exosomal miRNAs involved in tumor microenvironments

From: Exosomal miRNAs in tumor microenvironment

Host cellExosomal miRNAsTarget mRNAInvolved meleculsFunctionReference
OCmiR-124SPHK1α-SMA, FAPReshaping ECM[101, 102]
MyelomamiR-27-3p, miR-214-3pFBXW7α-SMA, FAPReshaping ECM[103, 104]
GCmiR-27aCSRP2α-SMAReshaping ECM[105]
CRCmiR-10bPIK3CAα-SMA, TGF-βReshaping ECM[106, 107]
CRCmiR-2149-5p, miR-6737-5p, miR-6819-5p TP53Reshaping ECM[108]
MelanomamiR-155SOCS1FGF2Reshaping ECM[109, 110]
HCCmiR-21PTENbFGF, TGF-βReshaping ECM[111, 112]
HCCmiR-1247B4GALT3β1-integrin-NF-κBReshaping ECM[113]
Breast cancermiR-9 MMP1, EFEMP1, COL1A1Reshaping ECM[30]
Breast cancermiR-105 MYCReshaping ECM[18]
CAFsmiR-148bDNMT1EMT-related moleculesPromoting metastasis[65]
CAFsmiR-196aCDKN1B, ING5P21, CDK2, CDK4, Cyclin D1 and Cyclin E1Chemotherapy resistance[115]
CAFsmiR-522 ALOX15Chemotherapy resistance[12]
NPCmiR-23aTSGA10p-ERKPromoting angiogenesis[121, 122]
GliomamiR-21 VEGF, p-FLK,
VEGFR2
Promoting angiogenesis[123, 124]
HCCmiR-210-3pSAMD4, STAT6 Promoting angiogenesis[125]
MSCsmiR-100 mTOR, HIF-1α,
VEGF
Promoting angiogenesis[127]
NSCLCmiR-619-5p RCAN1.4Promoting angiogenesis[128]
OCmiR-205PTENp-AKT, p-ERKPromoting angiogenesis[129]
CRCmiR-25-3pKLF2VEGFR2, p-AKT,
p-ERK
Promoting angiogenesis[130]
CRCmiR-25-3pKLF4ZO-1, Occludin,
Claudin5
Promoting angiogenesis[130]
Lung cancermiR-23aPHD1, PHD2, ZO-1HIF-1αPromoting angiogenesis[132]
GliomamiR-9MYC, OCT4MYC, OCT4Promoting angiogenesis[133]
HCCmiR-451LPIN1 Inhibiting angiogenesis[134]
NPCmiR-9MDKPDK, AKTInhibiting angiogenesis[135]
Pancreatic cancermiR-212-3pRFXAPHLA-DR, -DP, -DQ moleculesSuppressing immune[145, 146]
Pancreatic cancermiR-203TLR4, TNF-α, IL-12TLR4, TNF-α, IL-12Suppressing immune[147]
Breast cancermiR-let-7i TGF-β, IFNγ, TLR4Suppressing immune[148]
TregmiR-150-5p, miR-142-3pIL-10, IL-6IL-10, IL-6ISuppressing immune[149]
TregmiR-let-7d IFNγSuppressing immune[150]
NSCLCmiR-125b p53Enhancing immune[154]
MelanomamiR-125b-5pLIPAIl-1β, CCL1, CCL2, CD80Enhancing immune[71]
Head and neck cancermiR-21MRC1MRC1Suppressing immune[155]
EOCmiR-222-3pSOCS3p-STAT3Suppressing immune[156]
EOCmiR-21-3p, miR-125b-5p, miR-181d-5p, miR-940  Suppressing immune[157, 158]
Pancreatic cancermiR-301a-3pPTENp-mTOR, p-AKT, PI3K p110γSuppressing immune[159, 160]
Colon cancermiR-1246 IL-10, TGF-β, MMPsSuppressing immune[161]
GliomamiR-10aRORAp53Suppressing immune[165]
GliomamiR-21PTENp-STAT3, p-p65, p-AKTSuppressing immune[165]
CLLmiR-155 p-STAT1, NF-κSuppressing immune[166]
MDSCsmiR-126a IL-13, IL-33Promoting angiogenesis[167]