Exosomal miRNAs in tumor microenvironment

Tan, Shiming; Xia, Longzheng; Yi, Pin; Han, Yaqian; Tang, Lu; Pan, Qing; Tian, Yutong; Rao, Shan; Oyang, Linda; Liang, Jiaxin; Lin, Jinguan; Su, Min; Shi, Yingrui; Cao, Deliang; Zhou, Yujuan; Liao, Qianjin

doi:10.1186/s13046-020-01570-6

Journal of Experimental & Clinical Cancer Research

Table 1 Exosomal miRNAs involved in tumor microenvironments

From: Exosomal miRNAs in tumor microenvironment

Host cell	Exosomal miRNAs	Target mRNA	Involved meleculs	Function	Reference
OC	miR-124	SPHK1	α-SMA, FAP	Reshaping ECM	[101, 102]
Myeloma	miR-27-3p, miR-214-3p	FBXW7	α-SMA, FAP	Reshaping ECM	[103, 104]
GC	miR-27a	CSRP2	α-SMA	Reshaping ECM	[105]
CRC	miR-10b	PIK3CA	α-SMA, TGF-β	Reshaping ECM	[106, 107]
CRC	miR-2149-5p, miR-6737-5p, miR-6819-5p		TP53	Reshaping ECM	[108]
Melanoma	miR-155	SOCS1	FGF2	Reshaping ECM	[109, 110]
HCC	miR-21	PTEN	bFGF, TGF-β	Reshaping ECM	[111, 112]
HCC	miR-1247	B4GALT3	β1-integrin-NF-κB	Reshaping ECM	[113]
Breast cancer	miR-9		MMP1, EFEMP1, COL1A1	Reshaping ECM	[30]
Breast cancer	miR-105		MYC	Reshaping ECM	[18]
CAFs	miR-148b	DNMT1	EMT-related molecules	Promoting metastasis	[65]
CAFs	miR-196a	CDKN1B, ING5	P21, CDK2, CDK4, Cyclin D1 and Cyclin E1	Chemotherapy resistance	[115]
CAFs	miR-522		ALOX15	Chemotherapy resistance	[12]
NPC	miR-23a	TSGA10	p-ERK	Promoting angiogenesis	[121, 122]
Glioma	miR-21		VEGF, p-FLK, VEGFR2	Promoting angiogenesis	[123, 124]
HCC	miR-210-3p	SAMD4, STAT6		Promoting angiogenesis	[125]
MSCs	miR-100		mTOR, HIF-1α, VEGF	Promoting angiogenesis	[127]
NSCLC	miR-619-5p		RCAN1.4	Promoting angiogenesis	[128]
OC	miR-205	PTEN	p-AKT, p-ERK	Promoting angiogenesis	[129]
CRC	miR-25-3p	KLF2	VEGFR2, p-AKT, p-ERK	Promoting angiogenesis	[130]
CRC	miR-25-3p	KLF4	ZO-1, Occludin, Claudin5	Promoting angiogenesis	[130]
Lung cancer	miR-23a	PHD1, PHD2, ZO-1	HIF-1α	Promoting angiogenesis	[132]
Glioma	miR-9	MYC, OCT4	MYC, OCT4	Promoting angiogenesis	[133]
HCC	miR-451	LPIN1		Inhibiting angiogenesis	[134]
NPC	miR-9	MDK	PDK, AKT	Inhibiting angiogenesis	[135]
Pancreatic cancer	miR-212-3p	RFXAP	HLA-DR, -DP, -DQ molecules	Suppressing immune	[145, 146]
Pancreatic cancer	miR-203	TLR4, TNF-α, IL-12	TLR4, TNF-α, IL-12	Suppressing immune	[147]
Breast cancer	miR-let-7i		TGF-β, IFNγ, TLR4	Suppressing immune	[148]
Treg	miR-150-5p, miR-142-3p	IL-10, IL-6	IL-10, IL-6	ISuppressing immune	[149]
Treg	miR-let-7d		IFNγ	Suppressing immune	[150]
NSCLC	miR-125b		p53	Enhancing immune	[154]
Melanoma	miR-125b-5p	LIPA	Il-1β, CCL1, CCL2, CD80	Enhancing immune	[71]
Head and neck cancer	miR-21	MRC1	MRC1	Suppressing immune	[155]
EOC	miR-222-3p	SOCS3	p-STAT3	Suppressing immune	[156]
EOC	miR-21-3p, miR-125b-5p, miR-181d-5p, miR-940			Suppressing immune	[157, 158]
Pancreatic cancer	miR-301a-3p	PTEN	p-mTOR, p-AKT, PI3K p110γ	Suppressing immune	[159, 160]
Colon cancer	miR-1246		IL-10, TGF-β, MMPs	Suppressing immune	[161]
Glioma	miR-10a	RORA	p53	Suppressing immune	[165]
Glioma	miR-21	PTEN	p-STAT3, p-p65, p-AKT	Suppressing immune	[165]
CLL	miR-155		p-STAT1, NF-κ	Suppressing immune	[166]
MDSCs	miR-126a		IL-13, IL-33	Promoting angiogenesis	[167]

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ISSN: 1756-9966

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