Fig. 7
From: Extended half-life target module for sustainable UniCAR T-cell treatment of STn-expressing cancers
PET analysis of STn+ tumor-bearing mouse injected with [64Cu]Cu-NODAGA-αSTn-IgG4 TM. The TMs were conjugated with NODAGA, labeled with copper-64 (64Cu) and injected as a single bolus intravenously into NOD-SCID mice bearing established MDA-MB-231 STn+ Luc tumors. a Representative coronal view of the maximum intensity projection (MIP) of the [64Cu]Cu-NODAGA-αSTn-IgG4 TM distribution after 2, 7, 20, 47 and 66 h. Tumor is highlighted by yellow circles. b Time activity curves (TAC) of the dynamic PET analysis of regions of interest (ROI) obtained using the radiolabeled αSTn-IgG4 TM for blood, tumor and muscle. c Comparative view of blood TAC for the αSTn-IgG4 (red curve) and αSTn TMs (blue curve) over 66 h. SUV, standard uptake values