Fig. 2
From: Novel therapeutic strategies targeting telomere maintenance mechanisms in high-risk neuroblastoma
Molecular risk classification of neuroblastoma [6]. The presence of a telomere maintenance mechansim is defined as either MYCN amplification, a TERT rearrangement, telomerase upregulation or ALT. In neuroblastoma with a TMM the presence of a concurrent mutation in 1 of 17 defined RAS or TP53 pathway genes defines a group of patients with particularly poor outcomes. The most common RAS/TP53 pathway alterations found in neuroblastoma are activating ALK mutations