Fig. 1

Mutational profile of CRC patients evaluated by NGS analysis. a Pie chart showing frequency of the mutations detected in tumor samples from the CRC patients evaluated in the study. b Pie chart showing distribution of patients according to the number of mutations (from 0 to 7) simultaneously detected for each sample. For each condition, the number of patients is reported in the brackets. c Scheme showing the distribution of patients carrying mutated forms of TP53 (red), PIK3Ca (green), KRAS (blue), APC (orange) or KDR (purple), singularly or in combination (from 2 to 5 simultaneous mutations). Number of patients is reported for each mutational profile. d Histograms showing the number of patients mutated (red bars) or wild-type (blue bars) for each evaluated gene (TP53, PIK3Ca, KRAS, APC or KDR)