Fig. 5

Inhibition of Sirt6 enhanced chemo-sensitivity in DLBCL samples. a-b shSirt6 cells and control cells were treated with various concentrations of doxorubicin or bendamusitine, CCK8 assay was conducted after 48 h. The cell proliferation of shSirt6 DLBCL cell lines was markedly reduced. All results are expressed as mean ± SD, n = 3. **p < 0.01; ***p < 0.001; ****p < 0.0001. c Western blot was conducted to assess the phosphorylated (p) protein levels of DNA damage signaling pathway. Cells transfected with shSirt6 were observed to have decreased expressions of phosphorylated ATR and phosphorylated Chk1