Fig. 8From: A ruthenium(II)-curcumin compound modulates NRF2 expression balancing the cancer cell death/survival outcome according to p53 statusSchematic representation of the effect of RuCUR in cancer cells. (a) RuCUR induced NRF2, degraded mutp53 and induced wtp53, although not the apoptotic activity. (b) NRF2 inhibition restored wtp53 apoptotic activity and further degraded mutp53, unbalancing the cell-fate toward cell deathBack to article page