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Table 2 Cox univariate regression analysis of the risk factors for death in CRC patients

From: Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer progression by cis-regulating the nearby gene MK5 and acting as a let-7f-1-3p sponge

Variablesa Overall survival Relapse-free survival  
HR (95% CI) P HR (95% CI) P
MK5-AS1 0.476 (0.309–0.734) 0.01 0.538 (0.358–0.808) 0.003
Age (year) 0.777 (0.501–1.203) 0.258 0.667 (0.439–1.015) 0.059
Gender 0.854 (0.561–1.301) 0.463 0.885 (0.581–1.348) 0.57
Tumor invasion depth 0.463 (0.312–0.688) < 0.001 0.48 (0.323–0.713) < 0.001
Lymph node metastasis 0.319 (0.19–0.536) < 0.001 0.355 (0.211–0.598) < 0.001
Distant metastasis 0.112 (0.033–0.383) < 0.001 0.228 (0.075–0.694) 0.009
TNM stage 0.412 (0.27–0.63) < 0.001 0.426 (0.279–0.653) < 0.001
  1. aMK5-AS1: low vs high; age: ≤60 vs > 60; gender: male vs female; Tumor invasion depth: T1–T2 vs T3–T4; Lymph node metastasis: N0 vs N1, N2, N3; TNM stage was ranked as I–II vs III–IV