Fig. 5
From: CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma
Cathepsin B mediates CD147-induced collective invasion. a-b. Western blot analysis of indicated proteins in Huh-7 (a) and HepG2 (b) cells transfected with indicated constructs. c-d. Quantitative analysis of migration ability of Huh-7 (c) and HepG2 (d) cells transfected with indicated constructs or treated with CA074. * p < 0.05, ** p < 0.01, *** p < 0.0001, one-way ANOVA. e. Representative images of HE staining of 3D cultures of Huh-7 and HepG2 cells transfected with indicated constructs or treated with CA074. Scale bar, 200 μm. Graph shows quantitative analysis of relative invasion distance. *** p < 0.0001, one-way ANOVA