Fig. 4

RND2 overexpression attenuates autophagy and apoptosis in an Intracranial Xenograft Model. a Mouse survival is shown by Kaplan-Meier curves. GFP groups, n = 12; GFP-RND2 groups, n = 12. *P < 0.05. P values were calculated using the log-rank test. b Representative images of mouse brain sections and quantification of tumour volumes from mice that were intracranially implanted with GFP and GFP-RND2 with indicated modifications. Scale bars, 1.0 mm. c Representative images of mouse brains. d The weight of tumours (GFP/GFP RND2 group – PBS group) were analysed. **P < 0.01. e IHC analyses of RND2, p62, LC3B, cleaved caspase-3 and Bcl-2 in mouse tumour sections