Fig. 5

Overexpression of chk2 induces tumor growth in nude mice. Male BALB/C nude mice were subcutaneously injected with chk2-overexpressed HCT16 and HT29 cells to establish xenograft tumor animal models (n = 5 per group). a Tumor volume in nude mice. b Tumor weight in nude mice. * p < 0.05 vs. oe-NC. Data are expressed as mean ± s.d. Data from two groups were compared using the unpaired t test. Data comparison at different time points was performed using repeated measures ANOVA, followed by Bonferroni post hoc test. Each experiment was repeated three times