Fig. 6

miR-141-overexpressing SCLC tumors grow faster and have increased microvessel densities. A-C. Tumor nodules developed from miR-141-overexpressing H446 cells were larger (B), were heavier (C) and had more external blood vessels (A). D-F. Tumor nodules developed from miR-141-overexpressing H1048 cells were larger (E), were heavier (F) and had more external blood vessels (D). G-H. The level of plasma exosomal miR-141 was higher in mice injected with miR-141-overexpressing H446 or H1048 cells than that in mice injected with negative control cells. I. Representative images of IHC staining of CD31 in paraffin-embedded tumor nodules. J and K. Both the percentage of CD31-positive cells in and the MVD of tumor nodules developed from miR-141-upregulated cells were higher than those developed from negative control cells. HPF, high power field