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Table 1 m6A modification regulators and their major biological functions

From: m6A modification in RNA: biogenesis, functions and roles in gliomas

Category m6A regulator Main functions References
Writers METTL3 miRNA regulates mRNA methylation through sequence complementation and cell reprogramming [47]
METTL3 Mediates m6A modification involved in the regulation of spermatogenesis in mouse [59]
METTL3 Mediates m6A modification involved in the regulation of mouse cerebellar development [63]
METTL14, WTAP, VIRMA,
RBM15, ZC3H13, METTL16
m6A methyltransferase complex component identification [9]
WTAP, METTL3, METTL14 WTAP, as a regulatory subunit, regulates the localization and substrate binding capacity of the catalytic subunits of the METTL3/METTL14 complex [26]
Erasers FTO As the first discovered demethylase, FTO can catalyse the demethylation of m6Am and m1A [75]
FTO Mediates m6A modification that can serve as a novel cis element to regulate mRNA splicing and adipocyte precursor cell differentiation [48]
ALKBH5 The second discovered demethylase; participates in the regulation of mRNA nuclear export and mouse sperm development [33]
Readers YTHDC1 YTHDC1 directly interacts with SRSF3 and SRSF10 to regulate alternative mRNA splicing [35]
YTHDC1 YTHDC1 interacts with SRSF3 and RNA nuclear export factor 1 (NXF1) to regulate mRNA nuclear export [37]
YTHDF1 YTHDF1 directly interacts with the translation initiation complex to promote the translation efficiency of m6A-modified RNA substrate [34]
YTHDF2 Mediates m6A modification involved in the regulation of mRNA decay [44]
YTHDF2, METTL3 Mediates m6A modification involved in the regulation of the differentiation of haematopoietic stem cells [57]
YTHDF1 and YTHDF3 YTHDF1 synergizes with YTHDF3 to regulate mRNA translation [76]
YTHDF2 and YTHDF3 YTHDF2 synergizes with YTHDF3 to mediate mRNA decay [36]
YTHDC2 YTHDC2 regulates mRNA translation or decay and mouse spermatogenesis [38]
IGF2BP1/2/3 Participates in m6A modification-mediated mRNA stability and translation [42]