Fig. 6

Effects of genetic manipulation of AMPK on GC cell proliferation, migration and invasion. a Effects of AMPK on cell proliferation in TRPV1-overexpressed BGC823 cells and in TRPV1-knockeddown MKN45 cells (***P < 0.001, ****P < 0.0001, n = 3). b Representative images of protein expression of cyclin D1 and MMP2 in TRPV1-overexpressed BGC823 cells transfected with AMPK-siRNA or TRPV1-knockeddown MKN45 cells transfected with AMPK-overexpression as well as their NC cells. c, d Summary data of cyclin D1 and MMP2 proteins in GC cells generated from the original data as in b (*P < 0.05, **P < 0.01, n = 3). e, f Effects of genetic manipulation of AMPK on cell migration and invasion in TRPV1-overexpressed BGC823 cells and TRPV1-knockeddown MKN45 cells. Representative images are shown on the left and summary data on the right (*P < 0.05, **P < 0.01, n = 3)