Fig. 2From: KRAS wild-type pancreatic ductal adenocarcinoma: molecular pathology and therapeutic opportunitiesA schematic representation of the MAPK pathway is here shown. As highlighted, B-RAF is an immediately downstream of RAS and triggers MAP 2 K1/MEK, which activates MAPK1/ERK2, important mediators of the entire MAPK pathway. The overall effects include block of apoptosis, stress response and cell proliferationBack to article page