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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Gallbladder cancer-associated fibroblasts promote vasculogenic mimicry formation and tumor growth in gallbladder cancer via upregulating the expression of NOX4, a poor prognosis factor, through IL-6-JAK-STAT3 signal pathway

Fig. 4

Microarray analysis of differential gene profiles in vivo. A, Affymetrix GeneChip Human 1.0ST array. (a1) Gene expression profile for GCAFs and NFs (red color denotes upregulation and green denotes downregulation). (a2) Gene ontology (GO) analysis (biological process) based on the classification of gene numbers, expression and significance probability. The red mark showed that the process of angiogenesis was significantly expressed. (a3) 466 upregulated genes (FC > 1.5) were identified in GCAFs/NFs, and NOX4 expression was significantly upregulated (FC = 2.58) in GCAFs compared with NFs. B, lncRNAs chip analysis of VM-related gene expression profile in GBC. (b1) Heatmap of gene chip. (b2) Venn modal analysis. (b3-b4) Venn modal analysis of upregulation genes showed the high-expression of STAT3 and NOX4 in 154 of VM-related genes. (b5), GO analysis, (upregulation, > 2 times). The results showed that the activation of IL-6 mediated JAK-STAT pathway during VM formation in GBC

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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