|
Variable
|
NOX4 expression [n (%)]
|
x2 value (P)
|
Spearman rank correlation, r (P)
|
|---|
|
Low
|
High
|
|---|
|
Age (y)
|
|
> 65
|
11 (34.3)
|
21 (65.7)
|
0.014 (0.885)
|
0.010 (0.886)
|
|
≤ 65
|
19 (35.8)
|
34 (64.2)
|
|
Gender
|
|
Male
|
18 (33.3)
|
27 (66.7) 28 (70)
|
0.006 (0.958)
|
0.009 (0.960)
|
|
Female
|
12 (30)
| |
|
Tumor location
|
|
Bottom
|
14 (30.4)
|
32 (69.6)
|
1.651 (0.350)
|
0.055 (0.605)
|
|
Neck and other
|
16 (41)
|
23 (59)
|
|
Tumor size (cm)
|
|
> 3
|
20 (41.3)
|
26 (58.7)
|
2.889 (0.077)
|
0.325 (0.434)
|
|
≤ 3
|
10 (25.6)
|
29 (74.4)
|
|
Histological types
|
|
Adenocarcinoma
|
29 (37)
|
52 (63)
|
0.024 (0.922)
|
0.027 (0.755)
|
|
Othera
|
1 (33.3)
|
3 (66.7)
|
|
Differentiation degree
|
|
High
|
10 (68.7)
|
6 (31.3)
|
9.725 (0.009) b
|
0.518 (0.001) b
|
|
Moderate
|
12 (44.4)
|
15 (55.6)
|
|
Poor
|
8 (19)
|
34 (81)
|
|
Liver metastases
|
|
(+)
|
9 (22.5)
|
31 (77.5)
|
5.691 (0.022) b
|
0.324 (0.028) b
|
|
(−)
|
21 (48.8)
|
24 (51.2)
|
|
Vascular invasion
|
|
(+)
|
17 (25.3)
|
50 (74.7)
|
8.678 (0.005) b
|
0.462 (0.002) b
|
|
(−)
|
13 (55.5)
|
5 (44.5)
|
|
Lymph node metastasis
|
|
(+)
|
18 (38.2)
|
29 (61.8)
|
0.021 (0.930)
|
0.026 (0.735)
|
|
(−)
|
12 (36.8)
|
26 (63.2)
|
|
Nevin staging
|
|
III, IV, V
|
19 (28.3)
|
48 (71.7)
|
4.433 (0.038) b
|
0.322 (0.035) b
|
|
I, II
|
11 (55.6)
|
7 (44.4)
|
|
Resection method
|
|
R1, R2
|
13 (31.7)
|
28 (68.3)
|
0.319 (0.572)
|
0.025 (0.768)
|
|
R0
|
17 (40.9)
|
27 (59.1)
|
|
VM
|
|
(+)
|
15 (68.2)
|
7 (31.8)
|
6.113 (0.020) b
|
0.389 (0.021) b
|
|
(−)
|
15 (23.8)
|
48 (76.2)
|
- asquamous cell carcinoma, adenosquamous carcinoma; bP < 0.05: statistically significant
