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Table 2 Correlation between NOX4 expression in tumor stroma and clinicopathological parameters in patients with gallbladder cancer

From: Gallbladder cancer-associated fibroblasts promote vasculogenic mimicry formation and tumor growth in gallbladder cancer via upregulating the expression of NOX4, a poor prognosis factor, through IL-6-JAK-STAT3 signal pathway

Variable NOX4 expression [n (%)] x2 value (P) Spearman rank correlation, r (P)
Low High
Age (y)
 > 65 11 (34.3) 21 (65.7) 0.014 (0.885) 0.010 (0.886)
 ≤ 65 19 (35.8) 34 (64.2)
Gender
 Male 18 (33.3) 27 (66.7) 28 (70) 0.006 (0.958) 0.009 (0.960)
 Female 12 (30)  
Tumor location
 Bottom 14 (30.4) 32 (69.6) 1.651 (0.350) 0.055 (0.605)
 Neck and other 16 (41) 23 (59)
Tumor size (cm)
 > 3 20 (41.3) 26 (58.7) 2.889 (0.077) 0.325 (0.434)
 ≤ 3 10 (25.6) 29 (74.4)
Histological types
 Adenocarcinoma 29 (37) 52 (63) 0.024 (0.922) 0.027 (0.755)
 Othera 1 (33.3) 3 (66.7)
Differentiation degree
 High 10 (68.7) 6 (31.3) 9.725 (0.009) b 0.518 (0.001) b
 Moderate 12 (44.4) 15 (55.6)
 Poor 8 (19) 34 (81)
Liver metastases
 (+) 9 (22.5) 31 (77.5) 5.691 (0.022) b 0.324 (0.028) b
 (−) 21 (48.8) 24 (51.2)
Vascular invasion
 (+) 17 (25.3) 50 (74.7) 8.678 (0.005) b 0.462 (0.002) b
 (−) 13 (55.5) 5 (44.5)
Lymph node metastasis
 (+) 18 (38.2) 29 (61.8) 0.021 (0.930) 0.026 (0.735)
 (−) 12 (36.8) 26 (63.2)
Nevin staging
 III, IV, V 19 (28.3) 48 (71.7) 4.433 (0.038) b 0.322 (0.035) b
 I, II 11 (55.6) 7 (44.4)
Resection method
 R1, R2 13 (31.7) 28 (68.3) 0.319 (0.572) 0.025 (0.768)
 R0 17 (40.9) 27 (59.1)
VM
 (+) 15 (68.2) 7 (31.8) 6.113 (0.020) b 0.389 (0.021) b
 (−) 15 (23.8) 48 (76.2)
  1. asquamous cell carcinoma, adenosquamous carcinoma; bP < 0.05: statistically significant