Long noncoding RNA UPK1A-AS1 indicates poor prognosis of hepatocellular carcinoma and promotes cell proliferation through interaction with EZH2

Table 1 Univariate and multivariate analyses of OS in TCGA cohort by Cox regression analysis

Variables	Univariate analysis			Multivariate analysis
Variables	HR	CI (95%)	P value	HR	CI (95%)	P value
Age(years)	1.502	0.821–2.748	0.285
Gender	1.364	0.742–2.506	0.185
Race	1.165	0.690–1.966	0.556
Histologic grade	1.687	1.023–2.783	0.124
HCC risk factor	0.472	0.263–0.848	0.015*	0.639	0.410–0.995	0.048*
Stage	2.552	1.584–4.112	0.000*	2.214	1.408–3.481	0.001*
Vascular invasion	0.561	0.336–0.936	0.120
AFP	0.560	0.304–1.035	0.704
New tumor event after initial treatment	1.035	0.628–1.707	0.631
UPK1A-AS1	2.043	1.299–3.397	0.036*	1.704	1.100–2.640	0.017*

Abbreviations: HBV hepatitis B virus, HCV hepatitis C virus, CI confidence interval, HR hazard radio
*The values had statistically significant differences

ISSN: 1756-9966