Fig. 1
From: Loss of PLK2 induces acquired resistance to temozolomide in GBM via activation of notch signaling
PLK2 is significantly down-regulated in TMZ resistant GBM. a, Microarray analysis for differentially expressed kinases (DEKs) in TMZ resistant cells versus Naïve cells using GEO database (GSE68029). b, Microarray analysis for DEKs in GBM versus non-tumor tissues in GEO database (GSE16011). c, Differential kinase expression analysis in GBM versus non-tumor tissues using TCGA GBM dataset. d, Venn diagram for down-regulated kinases in both three datasets of comparisons, indicating PLK2 was one of the most significantly down-regulated kinases in TMZ resistant cells as well as GBM tissues