Fig. 7

COP1 was required for KMT5A silencing-induced CD73 ubiquitination. a By analyzing ChIP-seq data of DLBCL, 864 selected genes were revealed to interact with H4K20 me1. b Expression levels of 20 E3 ligases selected by combining CHIP-seq analysis and GO annotations of E3 ligase. c COP1 downregulation restored CD73 expression. d COP1 knockdown DLBCL cells were treated with MG132 and subjected to coimmunoprecipitation and western blot analyses. e DLBCL cells were transfected with various plasmids, as indicated, and subjected to ubiquitination analysis. f DLBCL cells were transfected as indicated and subjected to coimmunoprecipitation and western blot analyses. g DLBCL cells were transfected as indicated and subjected to ubiquitination analysis. h-i Survival analysis of DLBCL patients classified according to KMT5A (h) or COP1 (i) expression