Fig. 1

CircSOD2 is highly expressed in HCC tumor tissues and liver cancer cell lines. a Demonstration of circSOD2 formation, F and R are divergent primers used for circSOD2 detection. b RT-qPCR results of circSOD2 expression in 19 HCC patient tumor tissues and adjacent normal liver tissues. N normal, C cancer. c circSOD2 expression in normal liver cell HL-7702 and liver cancer cell line HEPG2, HUH7, SK-HEP1, and HEP3B. d circSOD2 expression after treatment with 1 mg/ml RNase A, GAPDH was used as control. e circSOD2 expression after pulling down with AGO2 or IgG. f The overall survival of HCC patients with low or high expression of circSOD2 in HCC tissues were assessed by Kaplan-Meier survival analysis. *P < 0.05, **P < 0.01, ***P < 0.001