Fig. 6

Bromodomain inhibition with JQ1 alters relative histone peptide modification states in DIPG, in vitro. a Unsupervised hierarchical clustering of DIPG cell line SF8628 histone tail modification profiles reveals clustering by treatment condition. b-e Relative abundance of H3.1/3.3 K27, H3.3K36, and H4K20 peptide modification states in SF8628 cells are distinct after JQ1 treatment. f-g Relative abundance of H3K79me2 and H3K18ac peptides in SF8628 cell lines are distinct after JQ1 treatment. * p < 0.05 compared to DMSO group (independent-sample t test, two-tailed)